Jason Collins' Battle With Brain Cancer
- NBA legend and LGBTQ advocate Jason Collins, 47, has publicized his battle with aggressive stage 4 glioblastoma, a fast-growing brain cancer, a disease he says “came on incredibly fast” after experiencing unusual symptoms.
- He’s now pursuing advanced treatments, including targeted chemotherapy and personalized immunotherapy, in Singapore, since standard therapies are ineffective for his tumor.
- Glioblastoma (GBM), a grade 4 glioma, presents significant challenges for treatment due to its highly invasive nature, rapid growth, and resistance to most conventional therapies.
- While new treatment approaches are continually being explored through clinical trials, the standard of care for glioblastoma has remained largely consistent since 2005. It combines maximal safe surgical resection (surgery to remove as much of the cancer as possible) followed by chemotherapy and radiation. The typical course after surgery is chemotherapy and radiation therapy together, followed by additional chemotherapy.
- Clinical trials give patients a chance to try a treatment before it’s approved by the U.S. Food and Drug Administration (FDA), and that can potentially be life-changing for patients. Despite the great benefits that come from clinical trials, they also come with risks (like potential side effects that are not fully understood yet).
- Anyone interested in participating in clinical trials must first talk with their doctor to see if they would be a good fit. For help finding a clinical trial that’s right for you, try our easy-to use Clinical Trial Finder.
In a deeply personal op-ed for ESPN, Collins shared that a brief update issued by his family in recent months about a brain tumor was deliberately limited. At the time, he was not feeling up to to going public with his health journey, and those closest to him were still coming to terms with the diagnosis as they balanced understanding the diagnosis with preserving his privacy.
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He continued, “I had been having weird symptoms like this for a week or two, but unless something is really wrong, I’m going to push through. I’m an athlete.
“Something was really wrong, though. I was in the CT machine at UCLA for all of five minutes before the tech pulled me out and said they were going to have me see a specialist. I’ve had enough CTs in my life to know they last longer than five minutes and whatever the tech had seen on the first images had to be bad.
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He recounted that within hours of that CT scan, his loved ones noticed his mental sharpness and short-term memory rapidly fading. Doctors later confirmed he had an aggressive glioblastoma, a fast-growing brain cancer made especially dangerous by its location inside the skull and its spread toward the frontal lobe, the part of the brain that shapes personality and identity.
“My glioblastoma is ‘multiforme.’ Imagine a monster with tentacles spreading across the underside of my brain the width of a baseball. Officially they had to do a biopsy to determine it was a glioblastoma, but when it’s in a butterfly shape — already in both hemispheres of the brain — it is almost always a glio and it is impossible to fully resect without coming out of the surgery “different,” he explained further.
“The biopsy revealed that my glio had a growth factor of 30%, meaning that within a matter of weeks, if nothing were to be done, the tumor would run out of room and I’d probably be dead within six weeks to three months.
Expert Resources On Glioblastoma
- An Innovative Treatment Option For Glioblastoma: The Pros And Cons of Tumor Treating Fields
- Managing Glioblastoma Expectations and Exploring Treatment Options
- Standard of Care Treatment for Glioblastoma Multiforme (GBM)
- Treating Glioblastoma: How Radiation And Chemotherapy Work Together
- Tumor Treating Fields: A Unique Treatment Option for Glioblastoma
- A Message For Glioma Caregivers: How To Support Your Loved One Through A Diagnosis
- Diagnosing Gliomas — Resections and the Grading System
When he first learned the diagnosis, which he described as “wild” and exceptionally aggresive, he was largely out of it and doesn’t remember much of the hospital discussions with his husband and family. His husband, Brunson Green, pointed out that Collins lost interest in tennis and instead found comfort in quiet Korean soap operas.
Before stating how determined he is to fight cancer, just like his grandmother fought stage 4 stomach cancer, he said, “One thing I’ve always prided myself on is having the right people in my life. When I came out publicly as the first active gay basketball player in 2013, I told a lot of the people closest to me before I did so. I wasn’t worried it would leak before the story came out, because I trusted the people I told. And guess what? Nothing leaked. I got to tell my own story, the way I wanted to.
“And now I can honestly say, the past 12 years since have been the best of my life. Your life is so much better when you just show up as your true self, unafraid to be your true self, in public or private. This is me. This is what I’m dealing with.”
Collins, who is close with his twin brother Jarron, added that he and his family are determined not to let the cancer take him without putting up a fierce fight.
“We’re going to try to hit it first, in ways it’s never been hit: with radiation and chemotherapy and immunotherapy that’s still being studied but offers the most promising frontier of cancer treatment for this type of cancer,” he said.
His Treatment Plan
Collins noted that because of his tumor’s specific genetic profile, the usual temozolomide (TMZ) chemotherapy for glioblastoma is ineffective in his case.
He explained, “Currently I’m receiving treatment at a clinic in Singapore that offers targeted chemotherapy — using EDVs — a delivery mechanism that acts as a Trojan horse, seeking out proteins only found in glioblastomas to deliver its toxic payload past the blood-brain barrier and straight into my tumors.
“The goal is to keep fighting the progress of the tumors long enough for a personalized immunotherapy to be made for me, and to keep me healthy enough to receive that immunotherapy once it’s ready.”
Collins then stated that since his tumor cannot be removed surgically, the usual treatment of radiation and TMZ would likely give him only 11 to 14 months. He wants to try a therapy that could one day become the standard for others facing the same condition.
“I’m fortunate to be in a financial position to go wherever in the world I need to go to get treatment,” he told his readers.
“So if what I’m doing doesn’t save me, I feel good thinking that it might help someone else who gets a diagnosis like this one day.
We’re glad to see Collins is moving through his cancer journey with optimism, determination, and the willingness to share his story with the public.
His loved ones previously announced he was undergoing treatment for a brain tumor.
The statement, issued on Sept. 11, read, “NBA Ambassador and 13-year NBA veteran Jason Collins is currently undergoing treatment for a brain tumor. Jason and his family welcome your support and prayers and kindly ask for privacy as they dedicate their attention to Jason’s health and well-being.”
The following statement was issued today on behalf of Jason Collins and his family: pic.twitter.com/36lKwB7NiR
— NBA Communications (@NBAPR) September 11, 2025
Collins is showing the same courage and resilience now that he displayed nearly 12 years ago when he came out publicly in Sports Illustrated.
During his announcement, he said, “I didn’t set out to be the first openly gay athlete playing in a major American team sport. But since I am, I’m happy to start the conversation.
“I wish I wasn’t the kid in the classroom raising his hand and saying, ‘I’m different.’ If I had my way, someone else would have already done this. Nobody has, which is why I’m raising my hand.”
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Understanding Gliomas & Glioblastomas
A glioma is a tumor originating in the central nervous system (CNS), specifically in the brain or spinal cord. A glioma originates in glial cells. Glial cells are supportive cells in the brain that protect and maintain the neurons. These types of tumors can either be benign (non-cancerous) or malignant (cancerous).
“Glioma is a broad term that refers to a whole range of different types of primary brain tumors,” Dr. Alexandra Miller, Director of the Neuro-Oncologist Division at NYU Langone Health, previously SurvivorNet.
“They’re tumors that originate in the brain and very rarely spread outside the brain to other parts of the body.”
WATCH: Understanding Gliomas
Glioblastoma (GBM) is the most aggressive and lethal form of primary brain tumor. Classified as a Grade 4 glioma by the World Health Organization (WHO), glioblastoma presents significant challenges for treatment due to its highly invasive nature, rapid growth, and resistance to most conventional therapies.
As per the National Cancer Institute, the average survival rate is 15 months with treatment and less than six if left untreated. While there is a five-year survival rate of averaging 6 percent, those individuals will never be cancer-free. They must continue receiving radiation and chemotherapy for the rest of their lives.
Clinical trials help doctors better understand cancer and discover more effective treatment methods. They also allow patients to try a treatment before it’s approved by the U.S. Food and Drug Administration (FDA), which can potentially be life-changing.
WATCH: Clinical Trials can be Life-Saving
Understanding Glioblastoma Multiforme (GBM) & The Standard Of Care
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer. It grows rapidly and infiltrates surrounding brain tissue, making it challenging to treat. A diagnosis of glioblastoma is indeed overwhelming, but understanding your treatment options can empower you to make informed decisions about your care.
After you’ve had a full work-up, experts say getting a consultation at a treatment center that sees a lot of patients with brain cancer can be an extremely valuable step.
Dr. Randy Jensen, a neurosurgeon at Huntsman Cancer Institute in Salt Lake City, tells SurvivorNet that the standard of care for glioblastoma is typically to start with surgery.
“The standard of care for glioblastoma is to start off with a maximal safe resection, and that means having your surgeon pull out all the stops of anything they can do to maximize resection [removal],” Dr. Jensen explains.
While surgery is often where treatment starts, the treatment path for glioblastoma requires a comprehensive approach involving multiple medical specialties. Your care team may include neurosurgeons, medical oncologists, radiation oncologists, neuro-oncologists, and supportive care specialists.
The treatment approach for glioblastoma may consist of the following steps.
- Surgery: The first step in treatment is often surgical removal of the tumor, also known as resection. The goal of surgery is to remove as much of the tumor as possible while preserving neurological function. Complete removal is often difficult due to the tumor’s infiltrative nature, but reducing the tumor size can improve the effectiveness of subsequent treatments. In cases where surgery is not possible due to the tumor’s location, a biopsy may be performed to confirm the diagnosis.
- Radiation Therapy: Following surgery, most patients undergo radiation therapy to target any remaining cancer cells. Radiation uses high-energy X-rays or protons to damage the DNA of tumor cells, preventing them from growing and dividing. It is typically administered five days a week over a period of six weeks. Radiation therapy is a crucial component in slowing tumor progression and improving survival rates.
- Chemotherapy: Temozolomide (TMZ) is the standard chemotherapy drug used in glioblastoma treatment. It is taken orally and works by interfering with the tumor cells’ ability to replicate. TMZ is often used in combination with radiation therapy (concurrent chemoradiation) and then continued as maintenance therapy for several months.
- Tumor Treating Fields (TTFs): TTFs are a newer, non-invasive treatment option that uses alternating electrical fields to disrupt cancer cell division.
Dr. Jensen explains that after surgery for brain cancer, a tumor board meeting often occurs, where doctors with different specialties meet to assess the case together and decide the best way to proceed with treatment.
The purpose of the tumor board is to give brain cancer experts with different specialties the opportunity to discuss and decide on the best possible treatment approach.
Side Effects of Glioblastoma Treatment
Each glioblastoma treatment comes with potential side effects. Your medical team will work with you to manage these effects and improve your quality of life.
Surgery side effects can include:
- Swelling in the brain (edema), which may require steroids to reduce inflammation
- Neurological deficits, such as difficulty speaking, memory problems, or muscle weakness, depending on the tumor’s location
- Infection or bleeding at the surgical site
Radiation side effects can include:
- Fatigue, which can persist for weeks after treatment ends
- Hair loss in the treated area
- Skin irritation or redness
- Cognitive effects, such as difficulty concentrating or memory problems
Chemotherapy side effects can include:
- Nausea and vomiting
- Increased risk of infections due to lower white blood cell counts
- Fatigue
- Low blood platelet levels, which can increase the risk of bleeding or bruising
Tumor Treating Fields (TTFs) side effects can include:
- Skin irritation from the transducer arrays
- Mild to moderate headaches
- Scalp sensitivity
- Psychological adjustment to wearing the device for extended periods
When Are Tumor Treating Fields Used?
Tumor Treating Fields (TTFs) represent an exciting advancement in glioblastoma treatment. This therapy is designed to slow tumor growth without affecting healthy brain tissue.
TTFs use low-intensity, alternating electric fields to disrupt cancer cell division. This is achieved through a wearable device that delivers continuous therapy on the scalp. These fields interfere with the tumor cells’ ability to multiply, ultimately slowing or stopping tumor progression.
Two major clinical trials, EF-11 and EF-14, demonstrated that TTFs provide a survival benefit for glioblastoma patients:
- EF-11 Trial: This trial focused on recurrent glioblastoma and found that patients receiving TTF therapy had comparable survival rates to those receiving chemotherapy, but with fewer side effects
- EF-14 Trial: This trial demonstrated that newly diagnosed glioblastoma patients who used TTFs alongside standard chemotherapy had significantly improved survival compared to those who received chemotherapy alone
TTFs may be recommended in the following scenarios:
- Newly Diagnosed Glioblastoma: After surgery, radiation, and chemotherapy, TTFs can be integrated into the treatment plan to enhance survival rates. The device is typically used continuously for at least 18 hours per day to maximize its effectiveness.
- Recurrent Glioblastoma: For patients whose tumors have returned, TTFs may be an option to extend survival and manage disease progression.
Your healthcare team will assess your overall health, tumor characteristics, and previous treatments to determine if TTFs are suitable for you. Factors such as your ability to wear the device consistently and your comfort with its use will also be considered.
The Future of Glioblastoma Treatment
Research into new glioblastoma treatments is ongoing.
Some promising areas of focus include include immunotherapy and targeted therapies.
Clinical trials also offer access to experimental therapies that may improve outcomes. Patients interested in participating in clinical trials should discuss options with their oncologists.
Whether you sign the a clinical trial consent form or decline, remember why trials exist: to turn today’s maybe into tomorrow’s standard of care. If you join, you stand on the frontier where possibility becomes proof.
Questions for Your Doctor
If you have been diagnosed with glioblastoma, here are some questions you may consider asking your doctor:
- What stage is my brain cancer?
- What are the treatment options for my brain cancer?
- What are the risks and benefits of the recommended treatment?
- What are the side effects of the recommended treatment?
- How long will it take to recover from treatment, and will I be able to return to work and normal activities?
- What’s the likelihood that insurance will cover the recommended treatment
Contributing: SurvivorNet Staff
Learn more about SurvivorNet's rigorous medical review process.
